Advantages and limitations of clopidogrel response testing methods.
نویسندگان
چکیده
Clopidogrel is a thienopyridine that irreversibly inhibits platelet P2Y12 receptors and adenosine diphosphate (ADP) mediated platelet aggregation. It is a prodrug that requires activation in the liver by cytochrome P450 enzymes (CYP3A4, CYP3A5, CYP1A2, CYP2C9, CYP2C19, and/or CYP2B6) . Dual antiplatelet therapy with clopidogrel and aspirin has become the mainstay of treatment of patients with acute coronary syndromes undergoing percutaneous coronary intervention .
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عنوان ژورنال:
- Vojnosanitetski pregled
دوره 69 4 شماره
صفحات -
تاریخ انتشار 2012